DDL’s Blog: FormulationForum

Topical Drug Product Testing

See Dow Development Laboratories’ FormulationForum for blogs and articles on various topical drug product development topics of interest.

How many pea-sized amounts are you going to use?

January 26, 2023

Determining the dosing before you start to formulate is now a thing.

CMC Roadmap for Topical Drug Products

July 21, 2022

CMC is critical to a successful topical drug product program. Important aspects of CMC that are unique to topical products are discussed in this presentation.

Scale-Up of Topical Products: Math Matters

December 1, 2021

Warm up your geometry muscles and get out your calculator before you start scale-up of a topical product. Heating and cooling, mixing efficiencies, and mixing speeds change dramatically when the batch size is increased.

To Suspend or Not to Suspend

October 1, 2021

Suspending an API in a topical drug product can be an appropriate alternative to a dissolved API, and can lead to better product outcomes. The potential advantages associated with suspensions are sometimes overlooked when developing topical formulations.

Making pimple popping a thing of the past

August 30, 2021

Acneic skin can involve inflammation, comedones, excess sebum production and bacteria.

Ask a Formulator: What is the Purpose and Approach to Solubility Studies?

May 7, 2021

If you’re not part of the solution, you’re the precipitate: Solubility studies are an essential first step in topical formulation development. Read about the factors to consider when designing a solubility study for an API for use in a topical drug product.

Keeping the Bugs Away

May 5, 2021

Topical nonsterile Rx products are at risk for contamination. Inclusion of an appropriate preservative system and USP testing will ensure that the product is free of microbial contamination.